What Happens if Lyme Disease is Left Untreated?: Risks and Effects

Lyme disease is a severe infection caused by the bacterium Borrelia burgdorferi. Treatment should never be delayed, because if left untreated, Lyme disease can lead to serious health complications affecting multiple systems in the body.

This article explores what happens if Lyme disease is left untreated, the long-term effects, and why early diagnosis and intervention are critical to prevent chronic issues.

What are the Long-Term Effects of Lyme Disease if Left Untreated?

Untreated Lyme disease is dangerous and may lead to severe and sometimes irreversible conditions. Some of the long-term effects include:

  • Lyme arthritis – painful swelling in joints, especially the knees.

  • Neurological issues – such as memory problems, facial paralysis (Bell’s palsy), and difficulty concentrating.

  • Lyme carditis – heart complications like arrhythmia and heart failure.

Without early treatment, these symptoms can worsen and drastically affect the quality of life.

Nervous System Complications of Untreated Lyme Disease​

When Lyme disease spreads to the nervous system, it leads to a condition called neuroborreliosis. Possible symptoms include:

  • Neuropathy (tingling or numbness in limbs)

  • Facial paralysis (Bell’s palsy)

  • Inflammation of the brain and spinal cord

  • Cognitive impairment (memory loss, speech difficulties, poor concentration)

These neurological complications can become permanent if left untreated.

Can Untreated Lyme Disease Cause Chronic Arthritis?

Yes. Chronic Lyme arthritis is a common late-stage complication of untreated Lyme disease. It primarily affects large joints, such as the knees, and causes:

  • Persistent swelling

  • Severe joint pain

  • Stiffness and reduced mobility

Over time, joint damage may become permanent, requiring advanced interventions like surgery.

Cognitive Problems Caused by Untreated Lyme Disease

Another serious complication is Lyme brain, a term used to describe cognitive symptoms such as:

  • Memory loss

  • Difficulty focusing

  • Confusion or slowed processing

  • Speech difficulties

These issues occur when the bacteria invade the brain and trigger inflammation. In some cases, cognitive symptoms may persist even after treatment if the infection is allowed to progress for too long.

Permanent Damage from Untreated Lyme Disease

If untreated, Lyme disease can cause permanent and life-altering damage:

  • Joints – irreversible arthritis and chronic pain

  • Nervous system – facial paralysis, memory loss, and neuropathy

  • Heart – permanent heart rhythm abnormalities or failure

Such complications highlight why early detection and timely antibiotic treatment are critical.

When Should Lyme Disease Treatment Start to Prevent Complications?

Treatment should begin as early as possible, ideally within weeks of a tick bite or at the onset of symptoms such as:

  • Fever and fatigue

  • Headaches and muscle aches

  • Bull’s-eye rash (erythema migrans)

Early antibiotic therapy helps prevent the spread of infection and reduces the risk of chronic conditions such as Lyme arthritis, Lyme carditis, and neuroborreliosis.

Frequently Asked Questions (FAQ)

1. Can Lyme disease go away on its own without treatment?
No. Without proper antibiotic treatment, Lyme disease does not resolve on its own and may progress into chronic illness.

2. How long can Lyme disease stay dormant in the body?
Lyme bacteria can lie dormant for months or even years before triggering severe symptoms.

3. What is the most common long-term effect of untreated Lyme disease?
The most common is Lyme arthritis, which can become chronic and debilitating.

4. Can untreated Lyme disease cause death?
Though rare, untreated Lyme can cause severe heart complications (Lyme carditis) that may be life-threatening.

5. How soon should I see a doctor after a tick bite?
Immediately. Early diagnosis and antibiotics significantly reduce the risk of long-term complications.

References

  1. CDC on Lyme Disease Complications – The Centers for Disease Control and Prevention (CDC) explains how untreated Lyme disease can progress into arthritis, heart problems, and neurological disorders.
  2. Mayo Clinic – Lyme Disease Symptoms and Causes – Mayo Clinic provides detailed insights into early and late-stage Lyme disease symptoms, as well as the importance of timely treatment.

  3. NIH – Lyme Disease Research and Long-Term Effects – The National Institute of Health (NIH) highlights ongoing research on chronic Lyme disease, treatment approaches, and potential long-term health complications.

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